Macrorealism formalizes the seemingly intuitive notion that, in contrast with the principles of quantum mechanics, a physical system can be in a definite state at any given time and moreover its dynamical evolution is independent of the measurements performed on it. In this study, we carry out a comparative analysis between three-time Leggett–Garg-type inequalities and the conditions of no-signaling-in-time and arrow-of-time for macrorealism within the context of meson oscillations. Our findings indicate that, under given initial conditions, no violations of Leggett–Garg inequalities are observed. However, no-signaling-in-time conditions are found to be violated, thereby revealing the impossibility of applying a macrorealistic description to the physics of meson oscillations.