We study necessary and sufficient conditions for macrorealism (known as no-signaling-in-time and arrow-of-time conditions) in the context of neutrino flavor transitions, within both the plane wave description and the wave packet approach. We then compare the outcome of the above investigation with the implication of various formulations of Leggett-Garg inequalities. In particular, we show that the fulfillment of the addressed conditions for macrorealism in neutrino oscillations implies the fulfillment of Leggett--Garg inequalities, whereas the converse is not true. Finally, in the framework of wave packet approach, we also prove that, for distances longer than the coherence length, the no-signaling-in-time condition is always violated whilst Leggett-Garg inequalities are not.